Cargando…
Cellular response to small molecules that selectively stall protein synthesis by the ribosome
Identifying small molecules that inhibit protein synthesis by selectively stalling the ribosome constitutes a new strategy for therapeutic development. Compounds that inhibit the translation of PCSK9, a major regulator of low-density lipoprotein cholesterol, have been identified that reduce LDL chol...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436758/ https://www.ncbi.nlm.nih.gov/pubmed/30875366 http://dx.doi.org/10.1371/journal.pgen.1008057 |