Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K

The PI3K/AKT signaling pathway plays a role in most cellular functions linked to cancer progression, including cell growth, proliferation, cell survival, tissue invasion and angiogenesis. It is generally recognized that hyperactive PI3K/AKT1 are oncogenic due to their boost to cell survival, cell cy...

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Detalles Bibliográficos
Autores principales: Sizek, Herbert, Hamel, Andrew, Deritei, Dávid, Campbell, Sarah, Ravasz Regan, Erzsébet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436762/
https://www.ncbi.nlm.nih.gov/pubmed/30875364
http://dx.doi.org/10.1371/journal.pcbi.1006402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436762/
https://www.ncbi.nlm.nih.gov/pubmed/30875364
http://dx.doi.org/10.1371/journal.pcbi.1006402

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