Activation of the Endonuclease that Defines mRNA 3′ Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex

Cleavage and polyadenylation factor (CPF/CPSF) is a multi-protein complex essential for formation of eukaryotic mRNA 3ʹ ends. CPF cleaves pre-mRNAs at a specific site and adds a poly(A) tail. The cleavage reaction defines the 3ʹ end of the mature mRNA, and thus the activity of the endonuclease is hi...

Descripción completa

Detalles Bibliográficos
Autores principales: Hill, Chris H., Boreikaitė, Vytautė, Kumar, Ananthanarayanan, Casañal, Ana, Kubík, Peter, Degliesposti, Gianluca, Maslen, Sarah, Mariani, Angelica, von Loeffelholz, Ottilie, Girbig, Mathias, Skehel, Mark, Passmore, Lori A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436931/
https://www.ncbi.nlm.nih.gov/pubmed/30737185
http://dx.doi.org/10.1016/j.molcel.2018.12.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436931/
https://www.ncbi.nlm.nih.gov/pubmed/30737185
http://dx.doi.org/10.1016/j.molcel.2018.12.023

Ejemplares similares