FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation

FBXW2 inhibits proliferation of lung cancer cells by targeting SKP2 for degradation. Whether and how FBXW2 regulates tumor invasion and metastasis is previously unknown. Here, we report that FBXW2 is an E3 ligase for β-catenin. FBXW2 binds to β-catenin upon EGF-AKT1-mediated phosphorylation on Ser(5...

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Detalles Bibliográficos
Autores principales: Yang, Fei, Xu, Jie, Li, Hua, Tan, Mingjia, Xiong, Xiufang, Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437151/
https://www.ncbi.nlm.nih.gov/pubmed/30918250
http://dx.doi.org/10.1038/s41467-019-09289-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437151/
https://www.ncbi.nlm.nih.gov/pubmed/30918250
http://dx.doi.org/10.1038/s41467-019-09289-5

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