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Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions
Macrophages orchestrate immune responses by sensing and responding to pathogen-associated molecules. These responses are modulated by prior conditioning with cytokines such as interferons (IFNs). Type I and II IFN have opposing functions in many biological scenarios, yet macrophages directly stimula...
Autores principales: | Cheng, Quen, Behzadi, Faraz, Sen, Supriya, Ohta, Sho, Spreafico, Roberto, Teles, Rosane, Modlin, Robert L., Hoffmann, Alexander |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437173/ https://www.ncbi.nlm.nih.gov/pubmed/30918279 http://dx.doi.org/10.1038/s41598-019-40503-y |
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