Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration

Age-related degeneration of basal forebrain cholinergic neurons (BFCNs) is linked to cognitive impairment. The p75 neurotrophin receptor (p75(NTR)) has been proposed to mediate neuronal degeneration in aging. Therefore, we tested the hypothesis that modifying p75(NTR) function would prevent or rever...

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Detalles Bibliográficos
Autores principales: Xie, Youmei, Meeker, Rick B., Massa, Stephen M., Longo, Frank M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437186/
https://www.ncbi.nlm.nih.gov/pubmed/30918278
http://dx.doi.org/10.1038/s41598-019-41654-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437186/
https://www.ncbi.nlm.nih.gov/pubmed/30918278
http://dx.doi.org/10.1038/s41598-019-41654-8

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