Histone deacetylase inhibitors restore normal hippocampal synaptic plasticity and seizure threshold in a mouse model of Tuberous Sclerosis Complex

Abnormal synaptic plasticity has been implicated in several neurological disorders including epilepsy, dementia and Autism Spectrum Disorder (ASD). Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disorder that manifests with seizures, autism, and cognitive deficits. The abnormal in...

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Detalles Bibliográficos
Autores principales: Basu, Trina, O’Riordan, Kenneth J., Schoenike, Barry A., Khan, Nadia N., Wallace, Eli P., Rodriguez, Genesis, Maganti, Rama K., Roopra, Avtar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437206/
https://www.ncbi.nlm.nih.gov/pubmed/30918308
http://dx.doi.org/10.1038/s41598-019-41744-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437206/
https://www.ncbi.nlm.nih.gov/pubmed/30918308
http://dx.doi.org/10.1038/s41598-019-41744-7

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