OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs

Infections due to carbapenemase-producing Gram-negative pathogens are associated with limited treatment options and consequently lead to increased mortality and morbidity. In response, combinations of existing β-lactams and novel β-lactamase inhibitors, such as ceftazidime-avibactam (CAZ-AVI), have...

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Detalles Bibliográficos
Autores principales: Fröhlich, Christopher, Sørum, Vidar, Thomassen, Ane Molden, Johnsen, Pål Jarle, Leiros, Hanna-Kirsti S., Samuelsen, Ørjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437269/
https://www.ncbi.nlm.nih.gov/pubmed/30918055
http://dx.doi.org/10.1128/mSphere.00024-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437269/
https://www.ncbi.nlm.nih.gov/pubmed/30918055
http://dx.doi.org/10.1128/mSphere.00024-19

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