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OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs
Infections due to carbapenemase-producing Gram-negative pathogens are associated with limited treatment options and consequently lead to increased mortality and morbidity. In response, combinations of existing β-lactams and novel β-lactamase inhibitors, such as ceftazidime-avibactam (CAZ-AVI), have...
Autores principales: | Fröhlich, Christopher, Sørum, Vidar, Thomassen, Ane Molden, Johnsen, Pål Jarle, Leiros, Hanna-Kirsti S., Samuelsen, Ørjan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437269/ https://www.ncbi.nlm.nih.gov/pubmed/30918055 http://dx.doi.org/10.1128/mSphere.00024-19 |
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