A Population Pharmacokinetic Analysis Shows that Arylacetamide Deacetylase (AADAC) Gene Polymorphism and HIV Infection Affect the Exposure of Rifapentine

Rifapentine is a rifamycin used to treat tuberculosis. As is the case for rifampin, plasma exposures of rifapentine are associated with the treatment response. While concomitant food intake and HIV infection explain part of the pharmacokinetic variability associated with rifapentine, few studies hav...

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Detalles Bibliográficos
Autores principales: Francis, Jose, Zvada, Simbarashe P., Denti, Paolo, Hatherill, Mark, Charalambous, Salome, Mungofa, Stanley, Dawson, Rodney, Dorman, Susan, Gupte, Nikhil, Wiesner, Lubbe, Jindani, Amina, Harrison, Thomas S., Olagunju, Adeniyi, Egan, Deirdre, Owen, Andrew, McIlleron, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437540/
https://www.ncbi.nlm.nih.gov/pubmed/30670438
http://dx.doi.org/10.1128/AAC.01964-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437540/
https://www.ncbi.nlm.nih.gov/pubmed/30670438
http://dx.doi.org/10.1128/AAC.01964-18

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