Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity

Fusidic acid is the only fusidane-type antibiotic that has been clinically used. However, biosynthesis of this important molecule in fungi is poorly understood. We have recently elucidated the biosynthesis of fusidane-type antibiotic helvolic acid, which provides us with clues to identify a possible...

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Detalles Bibliográficos
Autores principales: Cao, Zhiqin, Li, Shaoyang, Lv, Jianming, Gao, Hao, Chen, Guodong, Awakawa, Takayoshi, Abe, Ikuro, Yao, Xinsheng, Hu, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437595/
https://www.ncbi.nlm.nih.gov/pubmed/30972287
http://dx.doi.org/10.1016/j.apsb.2018.10.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437595/
https://www.ncbi.nlm.nih.gov/pubmed/30972287
http://dx.doi.org/10.1016/j.apsb.2018.10.007

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