GO functional similarity clustering depends on similarity measure, clustering method, and annotation completeness

BACKGROUND: Biological knowledge, and therefore Gene Ontology annotation sets, for human genes is incomplete. Recent studies have reported that biases in available GO annotations result in biased estimates of functional similarities of genes, but it is still unclear what the effect of incompleteness...

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Detalles Bibliográficos
Autores principales: Liu, Meng, Thomas, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437941/
https://www.ncbi.nlm.nih.gov/pubmed/30917779
http://dx.doi.org/10.1186/s12859-019-2752-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437941/
https://www.ncbi.nlm.nih.gov/pubmed/30917779
http://dx.doi.org/10.1186/s12859-019-2752-2

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