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GO functional similarity clustering depends on similarity measure, clustering method, and annotation completeness
BACKGROUND: Biological knowledge, and therefore Gene Ontology annotation sets, for human genes is incomplete. Recent studies have reported that biases in available GO annotations result in biased estimates of functional similarities of genes, but it is still unclear what the effect of incompleteness...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437941/ https://www.ncbi.nlm.nih.gov/pubmed/30917779 http://dx.doi.org/10.1186/s12859-019-2752-2 |