Label-free target identification reveals oxidative DNA damage as the mechanism of a selective cytotoxic agent

Phenotypic screening can not only identify promising first-in-class drug candidates, but can also reveal potential therapeutic targets or neomorphic functions of known proteins. In this study, we identified target proteins of SB2001, a cytotoxic agent that acts specifically against HeLa human cervic...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Hankum, Park, Seung Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438152/
https://www.ncbi.nlm.nih.gov/pubmed/30996934
http://dx.doi.org/10.1039/c8sc05465g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438152/
https://www.ncbi.nlm.nih.gov/pubmed/30996934
http://dx.doi.org/10.1039/c8sc05465g

Ejemplares similares