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Label-free target identification reveals oxidative DNA damage as the mechanism of a selective cytotoxic agent
Phenotypic screening can not only identify promising first-in-class drug candidates, but can also reveal potential therapeutic targets or neomorphic functions of known proteins. In this study, we identified target proteins of SB2001, a cytotoxic agent that acts specifically against HeLa human cervic...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438152/ https://www.ncbi.nlm.nih.gov/pubmed/30996934 http://dx.doi.org/10.1039/c8sc05465g |