Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer’s disease neuropathology

INTRODUCTION: Alzheimer’s disease is a neurodegenerative disorder that is hypothesized to involve epigenetic dysregulation of gene expression in the brain. METHODS: We performed an epigenome-wide association study to identify differential DNA methylation associated with neuropathology in prefrontal...

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Detalles Bibliográficos
Autores principales: Smith, Rebecca G., Hannon, Eilis, De Jager, Philip L., Chibnik, Lori, Lott, Simon J., Condliffe, Daniel, Smith, Adam R., Haroutunian, Vahram, Troakes, Claire, Al-Sarraj, Safa, Bennett, David A., Powell, John, Lovestone, Simon, Schalkwyk, Leonard, Mill, Jonathan, Lunnon, Katie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438205/
https://www.ncbi.nlm.nih.gov/pubmed/29550519
http://dx.doi.org/10.1016/j.jalz.2018.01.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438205/
https://www.ncbi.nlm.nih.gov/pubmed/29550519
http://dx.doi.org/10.1016/j.jalz.2018.01.017

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