Cargando…

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer’s disease neuropathology

INTRODUCTION: Alzheimer’s disease is a neurodegenerative disorder that is hypothesized to involve epigenetic dysregulation of gene expression in the brain. METHODS: We performed an epigenome-wide association study to identify differential DNA methylation associated with neuropathology in prefrontal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smith, Rebecca G., Hannon, Eilis, De Jager, Philip L., Chibnik, Lori, Lott, Simon J., Condliffe, Daniel, Smith, Adam R., Haroutunian, Vahram, Troakes, Claire, Al-Sarraj, Safa, Bennett, David A., Powell, John, Lovestone, Simon, Schalkwyk, Leonard, Mill, Jonathan, Lunnon, Katie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438205/ https://www.ncbi.nlm.nih.gov/pubmed/29550519 http://dx.doi.org/10.1016/j.jalz.2018.01.017

Ejemplares similares

Cross-tissue methylomic profiling strongly implicates a role for cortex-specific deregulation of ANK1 in Alzheimer’s disease neuropathology
por: Lunnon, Katie, et al.
Publicado: (2014)

Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer’s disease
por: Smith, Adam R., et al.
Publicado: (2019)

Variation in 5-hydroxymethylcytosine across human cortex and cerebellum
por: Lunnon, Katie, et al.
Publicado: (2016)

Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum
por: Lunnon, Katie, et al.
Publicado: (2016)

Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes
por: Hannon, Eilis, et al.
Publicado: (2015)

Genome-wide characterization of mitochondrial DNA methylation in human brain
por: Devall, Matthew, et al.
Publicado: (2023)

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
por: Davies, Matthew N, et al.
Publicado: (2012)

The histone modification H3K4me3 is altered at the ANK1 locus in Alzheimer's disease brain
por: Smith, Adam R, et al.
Publicado: (2021)

Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue
por: Devall, Matthew, et al.
Publicado: (2017)

Transcriptional Signatures of Tau and Amyloid Neuropathology
por: Castanho, Isabel, et al.
Publicado: (2020)

Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia
por: Pidsley, Ruth, et al.
Publicado: (2014)

Is there a neuropathology difference between mild cognitive impairment and dementia?
por: Haroutunian, Vahram, et al.
Publicado: (2009)

Control tissue in brain banking: the importance of thorough neuropathological assessment
por: Nolan, M., et al.
Publicado: (2015)

Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions
por: Viana, Joana, et al.
Publicado: (2017)

Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains
por: Hannon, Eilis, et al.
Publicado: (2019)

DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types
por: Shireby, Gemma, et al.
Publicado: (2022)

Simulated surgical-type cerebral biopsies from post-mortem brains allows accurate neuropathological diagnoses in the majority of neurodegenerative disease groups
por: King, Andrew, et al.
Publicado: (2013)

Epigenomic and transcriptomic signatures of a Klinefelter syndrome (47,XXY) karyotype in the brain
por: Viana, Joana, et al.
Publicado: (2014)

Comparison of clinical and neuropathological diagnoses of neurodegenerative diseases in two centres from the Brains for Dementia Research (BDR) cohort
por: Selvackadunco, Sashika, et al.
Publicado: (2019)

Microglia Activation in the Brain as Inflammatory Biomarker of Alzheimer’s Disease Neuropathology and Clinical Dementia
por: Xiang, Zhongmin, et al.
Publicado: (2006)

5-hydroxymethylcytosine is highly dynamic across human fetal brain development
por: Spiers, Helen, et al.
Publicado: (2017)

Genetic risk for Alzheimer’s disease influences neuropathology via multiple biological pathways
por: Hannon, Eilis, et al.
Publicado: (2020)

HoxA9 binds and represses the Cebpa +8 kb enhancer
por: Peng, Lei, et al.
Publicado: (2019)

Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue
por: Wong, Chloe C Y, et al.
Publicado: (2019)

Genetic architecture of epigenetic and neuronal ageing rates in human brain regions
por: Lu, Ake T., et al.
Publicado: (2017)

Tissue-specific patterns of allelically-skewed DNA methylation
por: Marzi, Sarah J., et al.
Publicado: (2016)

Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
por: Mansell, Georgina, et al.
Publicado: (2019)

Methylation quantitative trait loci in the developing brain and their enrichment in schizophrenia-associated genomic regions
por: Hannon, Eilis, et al.
Publicado: (2015)

Axonal injury is detected by βAPP immunohistochemistry in rapid death from head injury following road traffic collision
por: Al-Sarraj, Safa, et al.
Publicado: (2022)

Methylomic trajectories across human fetal brain development
por: Spiers, Helen, et al.
Publicado: (2015)

Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum
por: Lu, Ake T., et al.
Publicado: (2016)

A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex
por: Smith, Rebecca G., et al.
Publicado: (2021)

Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course
por: Hughes, Amanda, et al.
Publicado: (2018)

Evaluation of nanopore sequencing for epigenetic epidemiology: a comparison with DNA methylation microarrays
por: Flynn, Robert, et al.
Publicado: (2022)

Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex
por: Shireby, Gemma L, et al.
Publicado: (2020)

The Neuropathological Diagnosis of Alzheimer’s Disease—The Challenges of Pathological Mimics and Concomitant Pathology
por: King, Andrew, et al.
Publicado: (2020)

Social mobility across the lifecourse and DNA methylation age acceleration in adults in the UK
por: Bao, Yanchun, et al.
Publicado: (2022)

ALS-FUS pathology revisited: singleton FUS mutations and an unusual case with both a FUS and TARDBP mutation
por: King, Andrew, et al.
Publicado: (2015)

Bigmelon: tools for analysing large DNA methylation datasets
por: Gorrie-Stone, Tyler J, et al.
Publicado: (2019)

Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits
por: Hannon, Eilis, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ktd0qmeils7dbnaobumul4ad1h