The role of mitochondrial labile iron in Friedreich's ataxia skin fibroblasts sensitivity to ultraviolet A

Mitochondrial labile iron (LI) is a major contributor to the susceptibility of skin fibroblasts to ultraviolet A (UVA)-induced oxidative damage leading to necrotic cell death via ATP depletion. Mitochondria iron overload is a key feature of the neurodegenerative disease Friedreich's ataxia (FRD...

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Detalles Bibliográficos
Autores principales: Reelfs, Olivier, Abbate, Vincenzo, Cilibrizzi, Agostino, Pook, Mark A., Hider, Robert C., Pourzand, Charareh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438355/
https://www.ncbi.nlm.nih.gov/pubmed/30778428
http://dx.doi.org/10.1039/c8mt00257f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438355/
https://www.ncbi.nlm.nih.gov/pubmed/30778428
http://dx.doi.org/10.1039/c8mt00257f

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