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A theoretical analysis of single molecule protein sequencing via weak binding spectra

We propose and theoretically study an approach to massively parallel single molecule peptide sequencing, based on single molecule measurement of the kinetics of probe binding (Havranek, et al., 2013) to the N-termini of immobilized peptides. Unlike previous proposals, this method is robust to both w...

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Detalles Bibliográficos
Autores principales: Rodriques, Samuel G., Marblestone, Adam H., Boyden, Edward S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438480/
https://www.ncbi.nlm.nih.gov/pubmed/30921350
http://dx.doi.org/10.1371/journal.pone.0212868