The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation

Krüppel-like factor 1 (KLF1) is an essential transcription factor for erythroid development, as demonstrated by Klf1 knockout mice which die around E14 due to severe anemia. In humans, >140 KLF1 variants, causing different erythroid phenotypes, have been described. The KLF1 Nan variant, a single...

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Detalles Bibliográficos
Autores principales: Cantú, Ileana, van de Werken, Harmen J. G., Gillemans, Nynke, Stadhouders, Ralph, Heshusius, Steven, Maas, Alex, Esteghamat, Fatemehsadat, Ozgur, Zeliha, van IJcken, Wilfred F. J., Grosveld, Frank, von Lindern, Marieke, Philipsen, Sjaak, van Dijk, Thamar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438607/
https://www.ncbi.nlm.nih.gov/pubmed/30921348
http://dx.doi.org/10.1371/journal.pone.0208659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438607/
https://www.ncbi.nlm.nih.gov/pubmed/30921348
http://dx.doi.org/10.1371/journal.pone.0208659

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