Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis

GWAS have identified 108 schizophrenia risk loci, but risk mechanisms for individual loci are largely unknown. Using developmental, genetic, and illness-based RNA sequencing expression analysis in human brain, we characterized the human brain transcriptome around these loci and found enrichment for...

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Detalles Bibliográficos
Autores principales: Jaffe, Andrew E., Straub, Richard E., Shin, Joo Heon, Tao, Ran, Gao, Yuan, Collado-Torres, Leonardo, Kam-Thong, Tony, Xi, Hualin S., Quan, Jie, Chen, Qiang, Colantuoni, Carlo, Ulrich, William S., Maher, Brady J., Deep-Soboslay, Amy, Cross, Alan J., Brandon, Nicholas J., Leek, Jeffrey T., Hyde, Thomas M., Kleinman, Joel E., Weinberger, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438700/
https://www.ncbi.nlm.nih.gov/pubmed/30050107
http://dx.doi.org/10.1038/s41593-018-0197-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438700/
https://www.ncbi.nlm.nih.gov/pubmed/30050107
http://dx.doi.org/10.1038/s41593-018-0197-y

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