Ablation of the Chaperone Protein ERdj5 Results in a Sjögren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients

Objective: Sjögren's syndrome (SS) is a chronic autoimmune disorder that affects mainly the exocrine glands. Endoplasmic reticulum (ER) stress proteins have been suggested to participate in autoimmune and inflammatory responses, either acting as autoantigens, or by modulating factors of inflamm...

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Detalles Bibliográficos
Autores principales: Apostolou, Eirini, Moustardas, Petros, Iwawaki, Takao, Tzioufas, Athanasios G., Spyrou, Giannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438897/
https://www.ncbi.nlm.nih.gov/pubmed/30967862
http://dx.doi.org/10.3389/fimmu.2019.00506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438897/
https://www.ncbi.nlm.nih.gov/pubmed/30967862
http://dx.doi.org/10.3389/fimmu.2019.00506

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