Novel Mannitol-Based Small Molecules for Inhibiting Aggregation of α-Synuclein Amyloids in Parkinson's Disease

The aggregation of the amyloidogenic protein α-synuclein (α-Syn) into toxic oligomers and mature fibrils is the major pathological hallmark of Parkinson's disease (PD). Small molecules that inhibit α-Syn aggregation thus may be useful therapeutics for PD. Mannitol and naphthoquinone-tryptophan...

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Detalles Bibliográficos
Autores principales: Paul, Ashim, Zhang, Bo-Dou, Mohapatra, Satabdee, Li, Gao, Li, Yan-Mei, Gazit, Ehud, Segal, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438916/
https://www.ncbi.nlm.nih.gov/pubmed/30968030
http://dx.doi.org/10.3389/fmolb.2019.00016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438916/
https://www.ncbi.nlm.nih.gov/pubmed/30968030
http://dx.doi.org/10.3389/fmolb.2019.00016

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