Single-cell assessment of transcriptome alterations induced by Scriptaid in early differentiated human haematopoietic progenitors during ex vivo expansion

Priming haematopoietic stem/progenitor cells (HSPCs) in vitro with specific chromatin modifying agents and cytokines under serum-free-conditions significantly enhances engraftable HSC numbers. We extend these studies by culturing human CD133+ HSPCs on nanofibre scaffolds to mimic the niche for 5-day...

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Detalles Bibliográficos
Autores principales: Hua, Peng, Kronsteiner, Barbara, van der Garde, Mark, Ashley, Neil, Hernandez, Diana, Tarunina, Marina, Hook, Lilian, Choo, Yen, Roberts, Irene, Mead, Adam, Watt, Suzanne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438964/
https://www.ncbi.nlm.nih.gov/pubmed/30923342
http://dx.doi.org/10.1038/s41598-019-41803-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438964/
https://www.ncbi.nlm.nih.gov/pubmed/30923342
http://dx.doi.org/10.1038/s41598-019-41803-z

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