Ex vivo Hsp70-Activated NK Cells in Combination With PD-1 Inhibition Significantly Increase Overall Survival in Preclinical Models of Glioblastoma and Lung Cancer

Heat shock protein 70 (Hsp70) which is expressed on the plasma membrane of highly aggressive tumors including non-small cell lung carcinoma and glioblastoma multiforme serves as a target for Hsp70-targeting NK cells. Herein, we aimed to investigate the antitumor effects of a combined therapy consist...

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Detalles Bibliográficos
Autores principales: Shevtsov, Maxim, Pitkin, Emil, Ischenko, Alexander, Stangl, Stefan, Khachatryan, William, Galibin, Oleg, Edmond, Stanley, Lobinger, Dominik, Multhoff, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439337/
https://www.ncbi.nlm.nih.gov/pubmed/30967859
http://dx.doi.org/10.3389/fimmu.2019.00454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439337/
https://www.ncbi.nlm.nih.gov/pubmed/30967859
http://dx.doi.org/10.3389/fimmu.2019.00454

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