An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model

Tumor necrosis factor-alpha (TNF-α), an established pro-inflammatory cytokine plays a central role in the induction and progression of several chronic inflammatory and autoimmune diseases. Targeting TNF-α as a treatment modality has shown tremendous success, however there are several limitations ass...

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Detalles Bibliográficos
Autores principales: Ubah, Obinna C., Steven, John, Porter, Andrew J., Barelle, Caroline J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439398/
https://www.ncbi.nlm.nih.gov/pubmed/30967865
http://dx.doi.org/10.3389/fimmu.2019.00526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439398/
https://www.ncbi.nlm.nih.gov/pubmed/30967865
http://dx.doi.org/10.3389/fimmu.2019.00526

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