The secreted APP ectodomain sAPPα, but not sAPPβ, protects neurons against Aβ oligomer-induced dendritic spine loss and increased tau phosphorylation

AIM: The amyloid precursor protein (APP) is endoproteolytically processed to generate either the neurotoxic beta-amyloid peptide (Aβ) or the secreted ectodomain APP alpha (sAPPα). While neurotrophic properties of sAPPα were suggested in several studies, it is still unclear if and how sAPPα counterac...

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Detalles Bibliográficos
Autores principales: Tackenberg, Christian, Nitsch, Roger M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Micro Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440141/
https://www.ncbi.nlm.nih.gov/pubmed/30922360
http://dx.doi.org/10.1186/s13041-019-0447-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440141/
https://www.ncbi.nlm.nih.gov/pubmed/30922360
http://dx.doi.org/10.1186/s13041-019-0447-2

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