Hydrangenol suppresses VEGF-stimulated angiogenesis by targeting p27KIP1-dependent G1-cell cycle arrest, VEGFR-2-mediated signaling, and MMP-2 expression

We previously reported that hydrangenol has potent antitumor activity against human bladder cancer EJ cells. Here, we investigated the antiangiogenic activity of hydrangenol using in vitro and ex vivo models. Treatment with hydrangenol significantly inhibited the proliferation of vascular endothelia...

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Detalles Bibliográficos
Autores principales: Gho, Yujeong, Shin, Seung-Shick, Choi, Yung Hyun, Ko, Kisung, Kim, Wun-Jae, Moon, Sung-Kwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Molecular & Cellular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440517/
https://www.ncbi.nlm.nih.gov/pubmed/30949393
http://dx.doi.org/10.1080/19768354.2019.1578262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440517/
https://www.ncbi.nlm.nih.gov/pubmed/30949393
http://dx.doi.org/10.1080/19768354.2019.1578262

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