G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses

Leucine rich-repeat kinase 2 (LRRK2) is involved in the pathogenesis of Parkinson’s disease (PD). LRRK2 has kinase and GTPase activities, and mediates several cell functions, including vesicle trafficking, apoptosis, autophagy, mitochondrial dynamics, and neuroinflammation. G2019S (GS) is the most p...

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Detalles Bibliográficos
Autores principales: Ho, Dong Hwan, Lee, Heajin, Son, Ilhong, Seol, Wongi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Molecular & Cellular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440522/
https://www.ncbi.nlm.nih.gov/pubmed/30949397
http://dx.doi.org/10.1080/19768354.2019.1585948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440522/
https://www.ncbi.nlm.nih.gov/pubmed/30949397
http://dx.doi.org/10.1080/19768354.2019.1585948

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