Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization

Metastasis-initiating cells dynamically adapt to the distinct microenvironments of different organs, but these early adaptations are poorly understood due to the limited sensitivity of in situ transcriptomics. We developed fluorouracil-labeled RNA sequencing (Flura-seq) for in situ analysis with hig...

Descripción completa

Detalles Bibliográficos
Autores principales: Basnet, Harihar, Tian, Lin, Ganesh, Karuna, Huang, Yun-Han, Macalinao, Danilo G, Brogi, Edi, Finley, Lydia WS, Massagué, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440742/
https://www.ncbi.nlm.nih.gov/pubmed/30912515
http://dx.doi.org/10.7554/eLife.43627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440742/
https://www.ncbi.nlm.nih.gov/pubmed/30912515
http://dx.doi.org/10.7554/eLife.43627

Ejemplares similares