Conditional knockout of SHP2 in ErbB2 transgenic mice or inhibition in HER2-amplified breast cancer cell lines blocks oncogene expression and tumorigenesis

Overexpression of the human epidermal growth factor receptor 2 (HER2) is the cause of HER2-positive breast cancer (BC). Although HER2-inactivating therapies have benefited BC patients, development of resistance and disease recurrence have been the major clinical problems, pointing to a need for alte...

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Detalles Bibliográficos
Autores principales: Zhao, Hua, Martin, Elisha, Matalkah, Fatimah, Shah, Neal, Ivanov, Alexey, Ruppert, J. Michael, Lockman, Paul R., Agazie, Yehenew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440805/
https://www.ncbi.nlm.nih.gov/pubmed/30467378
http://dx.doi.org/10.1038/s41388-018-0574-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440805/
https://www.ncbi.nlm.nih.gov/pubmed/30467378
http://dx.doi.org/10.1038/s41388-018-0574-8

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