Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

For preclinical and clinical assessment of therapeutically relevant unbound, free, brain concentrations, the pharmacokinetic parameter fraction of unbound drug in brain (f(u,brain)) is commonly used to compensate total drug concentrations for nonspecific brain tissue binding (BTB). As, homogenous BT...

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Detalles Bibliográficos
Autores principales: Gustafsson, Sofia, Sehlin, Dag, Lampa, Erik, Hammarlund-Udenaes, Margareta, Loryan, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440985/
https://www.ncbi.nlm.nih.gov/pubmed/30926941
http://dx.doi.org/10.1038/s41598-019-41828-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440985/
https://www.ncbi.nlm.nih.gov/pubmed/30926941
http://dx.doi.org/10.1038/s41598-019-41828-4

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