Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans

The PERIOD2 (PER2) gene is a core molecular component of the circadian clock and plays an important role in the generation and maintenance of daily rhythms. Rs35333999, a missense variant of PER2 common in European populations, has been shown to associate with later chronotype. Chronotype relates to...

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Detalles Bibliográficos
Autores principales: Chang, Anne-Marie, Duffy, Jeanne F., Buxton, Orfeu M., Lane, Jacqueline M., Aeschbach, Daniel, Anderson, Clare, Bjonnes, Andrew C., Cain, Sean W., Cohen, Daniel A., Frayling, Timothy M., Gooley, Joshua J., Jones, Samuel E., Klerman, Elizabeth B., Lockley, Steven W., Munch, Mirjam, Rajaratnam, Shantha M. W., Rueger, Melanie, Rutter, Martin K., Santhi, Nayantara, Scheuermaier, Karine, Van Reen, Eliza, Weedon, Michael N., Czeisler, Charles A., Scheer, Frank A. J. L., Saxena, Richa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440993/
https://www.ncbi.nlm.nih.gov/pubmed/30926824
http://dx.doi.org/10.1038/s41598-019-41712-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440993/
https://www.ncbi.nlm.nih.gov/pubmed/30926824
http://dx.doi.org/10.1038/s41598-019-41712-1

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