Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine

Large protein machines are tightly regulated through allosteric communication channels. Here we demonstrate the involvement of ultrafast conformational dynamics in allosteric regulation of ClpB, a hexameric AAA+ machine that rescues aggregated proteins. Each subunit of ClpB contains a unique coiled-...

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Detalles Bibliográficos
Autores principales: Mazal, Hisham, Iljina, Marija, Barak, Yoav, Elad, Nadav, Rosenzweig, Rina, Goloubinoff, Pierre, Riven, Inbal, Haran, Gilad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440998/
https://www.ncbi.nlm.nih.gov/pubmed/30926805
http://dx.doi.org/10.1038/s41467-019-09474-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440998/
https://www.ncbi.nlm.nih.gov/pubmed/30926805
http://dx.doi.org/10.1038/s41467-019-09474-6

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