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Computer aided protein engineering to enhance the thermo-stability of CXCR1- T4 lysozyme complex
CXCR1, a member in G-protein coupled receptor (GPCR) family, binds to chemokine interleukin-8 (IL-8) specifically and transduces signals to mediate immune and inflammatory responses. Despite the importance of CXCR1, high-resolution structure determination is hindered by the challenges in crystalliza...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441008/ https://www.ncbi.nlm.nih.gov/pubmed/30926935 http://dx.doi.org/10.1038/s41598-019-41838-2 |