The anti-cancer drugs curaxins target spatial genome organization

Recently we characterized a class of anti-cancer agents (curaxins) that disturbs DNA/histone interactions within nucleosomes. Here, using a combination of genomic and in vitro approaches, we demonstrate that curaxins strongly affect spatial genome organization and compromise enhancer-promoter commun...

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Detalles Bibliográficos
Autores principales: Kantidze, Omar L., Luzhin, Artem V., Nizovtseva, Ekaterina V., Safina, Alfiya, Valieva, Maria E., Golov, Arkadiy K., Velichko, Artem K., Lyubitelev, Alexander V., Feofanov, Alexey V., Gurova, Katerina V., Studitsky, Vasily M., Razin, Sergey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441033/
https://www.ncbi.nlm.nih.gov/pubmed/30926878
http://dx.doi.org/10.1038/s41467-019-09500-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441033/
https://www.ncbi.nlm.nih.gov/pubmed/30926878
http://dx.doi.org/10.1038/s41467-019-09500-7

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