Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation

Stabilisation of stalled replication forks prevents excessive fork reversal and their pathological degradation, which can undermine genome integrity. Here we investigate a physiological role of RAD52 at stalled replication forks by using human cell models depleted of RAD52, a specific small-molecule...

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Detalles Bibliográficos
Autores principales: Malacaria, Eva, Pugliese, Giusj Monia, Honda, Masayoshi, Marabitti, Veronica, Aiello, Francesca Antonella, Spies, Maria, Franchitto, Annapaola, Pichierri, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441034/
https://www.ncbi.nlm.nih.gov/pubmed/30926821
http://dx.doi.org/10.1038/s41467-019-09196-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441034/
https://www.ncbi.nlm.nih.gov/pubmed/30926821
http://dx.doi.org/10.1038/s41467-019-09196-9

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