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Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating
Neuroglobin (Ngb) is predominantly expressed in neurons of the central and peripheral nervous systems and it clearly seems to be involved in neuroprotection. Engineering Ngb to observe structural and dynamic alterations associated with perturbation in ligand binding might reveal important structural...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441039/ https://www.ncbi.nlm.nih.gov/pubmed/30926858 http://dx.doi.org/10.1038/s41598-019-41780-3 |