K336I mutant actin alters the structure of neighbouring protomers in filaments and reduces affinity for actin-binding proteins

Mutation of the Lys-336 residue of actin to Ile (K336I) or Asp (K336E) causes congenital myopathy. To understand the effect of this mutation on the function of actin filaments and gain insight into the mechanism of disease onset, we prepared and biochemically characterised K336I mutant actin from Di...

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Detalles Bibliográficos
Autores principales: Umeki, Nobuhisa, Shibata, Keitaro, Noguchi, Taro Q. P., Hirose, Keiko, Sako, Yasushi, Uyeda, Taro Q. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441083/
https://www.ncbi.nlm.nih.gov/pubmed/30926871
http://dx.doi.org/10.1038/s41598-019-41795-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441083/
https://www.ncbi.nlm.nih.gov/pubmed/30926871
http://dx.doi.org/10.1038/s41598-019-41795-w

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