Analysis of the stability and affinity of BlaR-CTD protein to β-lactam antibiotics based on docking and mutagenesis studies

Owing to the thermal instability and low affinity of BlaR-CTD to some β-lactams, the receptor assay based on BlaR-CTD is limited in the detection of abundant variety of drugs and the result is often unstable. In this study, the three-dimensional structure of BlaR-CTD from Bacillus licheniformis ATCC...

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Detalles Bibliográficos
Autores principales: Ning, Jianan, Ahmed, Saeed, Cheng, Guyue, Chen, Ting, Wang, Yulian, Peng, Dapeng, Yuan, Zonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441189/
https://www.ncbi.nlm.nih.gov/pubmed/30976316
http://dx.doi.org/10.1186/s13036-019-0157-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441189/
https://www.ncbi.nlm.nih.gov/pubmed/30976316
http://dx.doi.org/10.1186/s13036-019-0157-4

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