Strategies for the Induction of Immune Tolerance to Enzyme Replacement Therapy in Mucopolysaccharidosis Type I

Enzyme replacement therapy with laronidase is an established treatment for Mucopolysaccharidosis type I (MPS I), but its efficacy may be limited by the development of anti-drug antibodies, which inhibit cellular uptake of the enzyme. In a related disorder, infantile Pompe disease, immune tolerance i...

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Detalles Bibliográficos
Autores principales: Ghosh, Arunabha, Liao, Aiyin, O’Leary, Claire, Mercer, Jean, Tylee, Karen, Goenka, Anu, Holley, Rebecca, Jones, Simon A., Bigger, Brian W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441787/
https://www.ncbi.nlm.nih.gov/pubmed/30976609
http://dx.doi.org/10.1016/j.omtm.2019.02.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441787/
https://www.ncbi.nlm.nih.gov/pubmed/30976609
http://dx.doi.org/10.1016/j.omtm.2019.02.007

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