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PI3K inhibitors protect against glucocorticoid-induced skin atrophy

BACKGROUND: Skin atrophy is a major adverse effect of topical glucocorticoids. We recently reported that REDD1 (regulated in development and DNA damage 1) and FKBP51 (FK506 binding protein 5), negative regulators of mTOR/Akt signaling, are induced by glucocorticoids in mouse and human skin and are c...

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Detalles Bibliográficos
Autores principales: Agarwal, Shivani, Mirzoeva, Salida, Readhead, Ben, Dudley, Joel T., Budunova, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441871/
https://www.ncbi.nlm.nih.gov/pubmed/30737086
http://dx.doi.org/10.1016/j.ebiom.2019.01.055