Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability

Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss-of-function mutations in WRN led to premature aging and predisposition to cancer. We evaluated synthetic lethal (SL) interactions between WRN and another human RecQ helicase, BLM, with DNA d...

Descripción completa

Detalles Bibliográficos
Autores principales: Kategaya, Lorn, Perumal, Senthil K., Hager, Jeffrey H., Belmont, Lisa D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441948/
https://www.ncbi.nlm.nih.gov/pubmed/30898619
http://dx.doi.org/10.1016/j.isci.2019.02.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441948/
https://www.ncbi.nlm.nih.gov/pubmed/30898619
http://dx.doi.org/10.1016/j.isci.2019.02.006

Ejemplares similares