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Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability
Werner syndrome protein (WRN) is a RecQ enzyme involved in the maintenance of genome integrity. Germline loss-of-function mutations in WRN led to premature aging and predisposition to cancer. We evaluated synthetic lethal (SL) interactions between WRN and another human RecQ helicase, BLM, with DNA d...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441948/ https://www.ncbi.nlm.nih.gov/pubmed/30898619 http://dx.doi.org/10.1016/j.isci.2019.02.006 |