Assessing the impact of efficacy stopping rules on the error rates under the multi-arm multi-stage framework

BACKGROUND: The multi-arm multi-stage framework uses intermediate outcomes to assess lack-of-benefit of research arms at interim stages in randomised trials with time-to-event outcomes. However, the design lacks formal methods to evaluate early evidence of overwhelming efficacy on the definitive out...

Descripción completa

Detalles Bibliográficos
Autores principales: Blenkinsop, Alexandra, Parmar, Mahesh KB, Choodari-Oskooei, Babak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442021/
https://www.ncbi.nlm.nih.gov/pubmed/30648428
http://dx.doi.org/10.1177/1740774518823551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442021/
https://www.ncbi.nlm.nih.gov/pubmed/30648428
http://dx.doi.org/10.1177/1740774518823551

Ejemplares similares