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Assessing the impact of efficacy stopping rules on the error rates under the multi-arm multi-stage framework
BACKGROUND: The multi-arm multi-stage framework uses intermediate outcomes to assess lack-of-benefit of research arms at interim stages in randomised trials with time-to-event outcomes. However, the design lacks formal methods to evaluate early evidence of overwhelming efficacy on the definitive out...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
SAGE Publications
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442021/ https://www.ncbi.nlm.nih.gov/pubmed/30648428 http://dx.doi.org/10.1177/1740774518823551 |