The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A

Mutations in the gene encoding for leucine-rich repeat kinase 2 (LRRK2) are a common cause of hereditary Parkinson's disease. LRRK2 regulates various intracellular vesicular trafficking pathways, including endolysosomal degradative events such as epidermal growth factor receptor (EGFR) degradat...

Descripción completa

Detalles Bibliográficos
Autores principales: Rivero-Ríos, Pilar, Romo-Lozano, María, Madero-Pérez, Jesús, Thomas, Andrew P., Biosa, Alice, Greggio, Elisa, Hilfiker, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442034/
https://www.ncbi.nlm.nih.gov/pubmed/30709905
http://dx.doi.org/10.1074/jbc.RA118.005008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442034/
https://www.ncbi.nlm.nih.gov/pubmed/30709905
http://dx.doi.org/10.1074/jbc.RA118.005008

Ejemplares similares