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The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A

Mutations in the gene encoding for leucine-rich repeat kinase 2 (LRRK2) are a common cause of hereditary Parkinson's disease. LRRK2 regulates various intracellular vesicular trafficking pathways, including endolysosomal degradative events such as epidermal growth factor receptor (EGFR) degradat...

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Detalles Bibliográficos
Autores principales:	Rivero-Ríos, Pilar, Romo-Lozano, María, Madero-Pérez, Jesús, Thomas, Andrew P., Biosa, Alice, Greggio, Elisa, Hilfiker, Sabine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442034/ https://www.ncbi.nlm.nih.gov/pubmed/30709905 http://dx.doi.org/10.1074/jbc.RA118.005008

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