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Transdermal metformin hydrochloride-loaded cubic phases: in silico formulation optimization, preparation, properties, and application for local treatment of melanoma

Metformin hydrochloride (Met) is commonly used for antidiabetic therapy though its antimelanoma action is also reported. Conventional oral administration method of Met is not appropriate for therapy of melanoma because of large dose, adverse reactions, and low efficiency. Here, a transdermal Met-loa...

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Detalles Bibliográficos
Autores principales: Yu, Xiang, Zhou, Wei, Wang, Hongmei, Lu, Sheng, Jin, Yiguang, Fu, Junhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442100/
https://www.ncbi.nlm.nih.gov/pubmed/30905216
http://dx.doi.org/10.1080/10717544.2019.1587046