Novel thienopyrimidine derivatives as dual EGFR and VEGFR-2 inhibitors: design, synthesis, anticancer activity and effect on cell cycle profile

Aim: Design and synthesis of thienopyrimidine derivatives as dual EGFR and VEGFR-2 inhibitors.Material and methods: A series of novel 6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidine derivatives with different substituents on C-4 position was synthesized and evaluated for their anticance...

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Detalles Bibliográficos
Autores principales: Mghwary, Aml E.-S., Gedawy, Ehab M., Kamal, Aliaa M., Abuel-Maaty, Suzan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442109/
https://www.ncbi.nlm.nih.gov/pubmed/30919701
http://dx.doi.org/10.1080/14756366.2019.1593160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442109/
https://www.ncbi.nlm.nih.gov/pubmed/30919701
http://dx.doi.org/10.1080/14756366.2019.1593160

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